Influenza Neuraminidase Inhibitors: Synthetic Approaches, Derivatives and Biological Activity
نویسندگان
چکیده
منابع مشابه
Neuraminidase inhibitors for influenza.
N Engl J Med 2005;353:1363-73. Copyright © 2005 Massachusetts Medical Society. he impact of influenza infection is felt globally each year when the disease develops in approximately 20 percent of the world’s population. In the United States, influenza infections occur in epidemics each winter, generally between late December and early March. Recent events, including human cases of avian influen...
متن کاملSynthetic approaches to the neuraminidase inhibitors zanamivir (Relenza) and oseltamivir phosphate (Tamiflu) for the treatment of influenza.
Influenza, a severe viral infection of the respiratory system, is responsible for a significant morbidity and mortality due to both annual epidemics and unpredictable pandemics. In the United States alone, 10-20% of the population is affected every year, which results in approximately 110,000 hospitalizations and more than 20,000 deaths with an estimated cost of U.S. $12 billion.1 In addition t...
متن کاملInfluenza viruses resistant to neuraminidase inhibitors.
Neuraminidase inhibitors (NAIs) are antiviral drugs for treatment and prophylaxis of influenza. By blocking the activity of the enzyme neuraminidase, NAIs prevent new viral particles from being released. The increasing use of NAIs brings into focus the risk of drug resistance arising to the class. There are three levels of antiviral resistance according to the way that resistance can be detecte...
متن کاملNeuraminidase inhibitors as anti-influenza virus agents.
Influenza virus neuraminidase (NA) catalyses the cleavage of sialic acid residues terminally linked to glycoproteins and glycolipids and plays an important role in the replication of the virus. Recently, several potent NA inhibitors have been synthesized based on the rational design of mimicking the transition state of the sialic acid cleavage. Zanamivir and oseltamivir (GS 4104, the prodrug of...
متن کاملSafety of neuraminidase inhibitors for influenza.
Neuraminidase inhibitors, oseltamivir and zanamivir, are used for the treatment of, and protection from, influenza. The safety of these compounds has been assessed in systematic reviews. However, the data presented are somewhat limited by the paucity of good quality adverse event data available. The majority of safety outcomes are based on evidence from just one or two randomised controlled tri...
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ژورنال
عنوان ژورنال: Molecules
سال: 2016
ISSN: 1420-3049
DOI: 10.3390/molecules21111513